I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| ciliated cell | 6 studies | 25% ± 5% | |
| retinal bipolar neuron | 3 studies | 23% ± 6% | |
| GABAergic neuron | 3 studies | 21% ± 4% | |
| glutamatergic neuron | 3 studies | 31% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| ciliated cell | 6 studies | 25% ± 5% | |
| retinal bipolar neuron | 3 studies | 23% ± 6% | |
| GABAergic neuron | 3 studies | 21% ± 4% | |
| glutamatergic neuron | 3 studies | 31% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 3 studies | 22% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| skin | 100% | 6281.89 | 1809 / 1809 | 100% | 71.12 | 472 / 472 |
| intestine | 100% | 4281.51 | 965 / 966 | 100% | 37.90 | 525 / 527 |
| breast | 100% | 4723.15 | 459 / 459 | 99% | 43.70 | 1109 / 1118 |
| brain | 98% | 5781.19 | 2598 / 2642 | 100% | 39.54 | 704 / 705 |
| thymus | 100% | 3347.32 | 651 / 653 | 98% | 32.89 | 594 / 605 |
| uterus | 100% | 4977.48 | 170 / 170 | 98% | 28.37 | 449 / 459 |
| lung | 100% | 6867.82 | 578 / 578 | 98% | 37.08 | 1128 / 1155 |
| stomach | 98% | 2462.21 | 353 / 359 | 99% | 35.40 | 284 / 286 |
| adrenal gland | 100% | 3261.72 | 258 / 258 | 97% | 50.42 | 224 / 230 |
| kidney | 100% | 3160.88 | 89 / 89 | 96% | 56.77 | 868 / 901 |
| bladder | 100% | 3811.33 | 21 / 21 | 96% | 32.73 | 482 / 504 |
| ovary | 100% | 3704.81 | 180 / 180 | 94% | 22.15 | 403 / 430 |
| esophagus | 93% | 3459.38 | 1338 / 1445 | 97% | 29.71 | 177 / 183 |
| pancreas | 89% | 1669.28 | 292 / 328 | 99% | 66.90 | 176 / 178 |
| prostate | 99% | 4016.67 | 243 / 245 | 83% | 14.47 | 416 / 502 |
| adipose | 100% | 5562.08 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 100% | 4060.02 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 38.50 | 1 / 1 |
| blood vessel | 100% | 7893.03 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 98% | 52.38 | 78 / 80 |
| heart | 96% | 2392.30 | 824 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 91% | 20.28 | 41 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 86% | 17.22 | 25 / 29 |
| peripheral blood | 76% | 1508.09 | 702 / 929 | 0% | 0 | 0 / 0 |
| liver | 16% | 230.14 | 37 / 226 | 43% | 12.51 | 175 / 406 |
| muscle | 23% | 297.03 | 183 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0034220 | Biological process | monoatomic ion transmembrane transport |
| GO_0015825 | Biological process | L-serine transport |
| GO_0140300 | Biological process | serine import into mitochondrion |
| GO_0006730 | Biological process | one-carbon metabolic process |
| GO_1990542 | Biological process | mitochondrial transmembrane transport |
| GO_0005743 | Cellular component | mitochondrial inner membrane |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0015194 | Molecular function | L-serine transmembrane transporter activity |
| GO_0015075 | Molecular function | monoatomic ion transmembrane transporter activity |
| GO_0022857 | Molecular function | transmembrane transporter activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | SFXN3 |
| Protein name | Sideroflexin-3 Sidoreflexin |
| Synonyms | |
| Description | FUNCTION: Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway . Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors . . |
| Accessions | A0A8V8TP06 A0A8V8TM72 ENST00000698791.1 Q9BWM7 ENST00000489434.3 S4R3N9 ENST00000393459.6 ENST00000698792.1 |
