SETD7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0006974Biological processDNA damage response
GO_0045471Biological processresponse to ethanol
GO_0006338Biological processchromatin remodeling
GO_0018026Biological processpeptidyl-lysine monomethylation
GO_0070828Biological processheterochromatin organization
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0018027Biological processpeptidyl-lysine dimethylation
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005694Cellular componentchromosome
GO_0005634Cellular componentnucleus
GO_0003682Molecular functionchromatin binding
GO_0042054Molecular functionhistone methyltransferase activity
GO_0016279Molecular functionprotein-lysine N-methyltransferase activity
GO_0002039Molecular functionp53 binding
GO_0140938Molecular functionhistone H3 methyltransferase activity
GO_0140945Molecular functionhistone H3K4 monomethyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSETD7
Protein nameHistone-lysine N-methyltransferase SETD7 (EC 2.1.1.364) (Histone H3-K4 methyltransferase SETD7) (H3-K4-HMTase SETD7) (Lysine N-methyltransferase 7) (SET domain-containing protein 7) (SET7/9)
SET domain containing 7, histone lysine methyltransferase
SynonymsSET7
SET9
KMT7
KIAA1717
DescriptionFUNCTION: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3 . H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation . Plays a central role in the transcriptional activation of genes such as collagenase or insulin . Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription . Has also methyltransferase activity toward non-histone proteins such as CGAS, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins . Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II . Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation . Monomethylates 'Lys-491' of CGAS, promoting interaction between SGF29 and CGAS (By similarity). .

AccessionsQ8WTS6
ENST00000506866.6
D6RJA0
ENST00000608795.5
B5MCZ8
ENST00000608958.1
ENST00000404104.7
ENST00000274031.8
V9GYG1
V9GY19