SETD6 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SETD6 at tissue level.

III. Associated gene sets

GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_0048863Biological processstem cell differentiation
GO_0019827Biological processstem cell population maintenance
GO_0050727Biological processregulation of inflammatory response
GO_0018026Biological processpeptidyl-lysine monomethylation
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_1904047Molecular functionS-adenosyl-L-methionine binding
GO_0005515Molecular functionprotein binding
GO_0016279Molecular functionprotein-lysine N-methyltransferase activity
GO_0051059Molecular functionNF-kappaB binding

IV. Literature review

[source]
Gene nameSETD6
Protein nameN-lysine methyltransferase SETD6 (EC 2.1.1.-) (SET domain-containing protein 6)
N-lysine methyltransferase SETD6 (SET domain-containing protein 6)
SET domain containing 6, protein lysine methyltransferase
Synonyms
DescriptionFUNCTION: Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulation of NF-kappa-B transcription factor activity . Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) . Required for the maintenance of embryonic stem cell self-renewal (By similarity). Methylates PAK4. .

AccessionsENST00000219315.9 [Q8TBK2-1]
J3QT10
H7C3N0
C9JCR1
ENST00000310682.6 [Q8TBK2-2]
ENST00000394266.8
ENST00000422445.5
ENST00000427443.5
Q8TBK2
E9PC53
ENST00000447443.1