SERTAD3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SERTAD3 at tissue level.

III. Associated gene sets

GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006355Biological processregulation of DNA-templated transcription
GO_0030308Biological processnegative regulation of cell growth
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSERTAD3
Protein nameSERTA domain-containing protein 3 (Replication protein-binding trans-activator) (RPA-binding trans-activator)
SERTA domain containing 3
SynonymsRBT1
DescriptionFUNCTION: Antiviral interferon-stimulated protein that plays a role in innate immunity and in the suppression of viruses through different mechanisms . Plays a role in the late phase response of TLR-induced immune effector expression (By similarity). During influenza infection, interacts with PB2, PB1, and PA to disrupt the formation of the viral RdRp complex . Inhibits zika virus by interacting with the capsid protein in the nucleolus and reducing its abundance through proteasomal degradation . Strong transcriptional coactivator . .

AccessionsENST00000599706.1
ENST00000596456.1
Q9UJW9
ENST00000322354.4
M0R352
ENST00000392028.8
M0QXL4