SEPSECS | OmnibusX

Name	Number of supported studies	Average coverage
hepatocyte	3 studies	22% ± 3%	Explore
interneuron	3 studies	20% ± 4%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of SEPSECS at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	2619.14	226 / 226	100%	14.76	404 / 406
thymus	100%	1459.13	653 / 653	99%	8.46	601 / 605
prostate	100%	998.39	245 / 245	99%	7.96	498 / 502
lung	100%	1145.71	577 / 578	99%	7.31	1145 / 1155
esophagus	100%	832.94	1445 / 1445	99%	8.93	181 / 183
pancreas	100%	1147.59	328 / 328	99%	8.93	176 / 178
kidney	100%	1347.56	89 / 89	99%	14.24	889 / 901
breast	100%	1340.85	459 / 459	98%	10.05	1101 / 1118
brain	98%	570.58	2595 / 2642	100%	8.27	705 / 705
stomach	100%	1069.65	359 / 359	98%	8.55	280 / 286
uterus	100%	1186.78	170 / 170	98%	6.68	449 / 459
intestine	100%	1379.34	966 / 966	98%	8.82	515 / 527
bladder	100%	1076.52	21 / 21	97%	6.49	488 / 504
ovary	100%	1310.62	180 / 180	91%	4.72	393 / 430
adrenal gland	100%	970.99	258 / 258	89%	4.41	205 / 230
skin	100%	1284.14	1809 / 1809	88%	6.17	417 / 472
adipose	100%	1169.60	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	7.34	29 / 29
spleen	100%	1552.14	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	4.06	1 / 1
blood vessel	100%	840.73	1333 / 1335	0%	0	0 / 0
muscle	98%	566.95	788 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	7.00	43 / 45
heart	94%	497.61	812 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	63%	3.78	50 / 80
peripheral blood	56%	449.54	519 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0001717	Biological process	conversion of seryl-tRNAsec to selenocys-tRNAsec
GO_0001514	Biological process	selenocysteine incorporation
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0098621	Molecular function	O-phosphoseryl-tRNA(Sec) selenium transferase activity
GO_0000049	Molecular function	tRNA binding
GO_0005515	Molecular function	protein binding

Gene name	SEPSECS
Protein name	O-phosphoseryl-tRNA(Sec) selenium transferase (EC 2.9.1.2) (Selenocysteine synthase) (Selenocysteinyl-tRNA(Sec) synthase) (Sep-tRNA:Sec-tRNA synthase) Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase O-phosphoseryl-tRNA(Sec) selenium transferase (EC 2.9.1.2) (Liver-pancreas antigen) (LP) (SLA-p35) (SLA/LP autoantigen) (Selenocysteine synthase) (Sec synthase) (Selenocysteinyl-tRNA(Sec) synthase) (Sep-tRNA:Sec-tRNA synthase) (SepSecS) (Soluble liver antigen) (SLA) (UGA suppressor tRNA-associated protein) (tRNA(Ser/Sec)-associated antigenic protein)
Synonyms	LP TRNP48 hCG_18250 SLA
Description	FUNCTION: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. . FUNCTION: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. . FUNCTION: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. . FUNCTION: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. . FUNCTION: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. .
Accessions	ENST00000680581.1 A0A7P0TA23 ENST00000681948.1 ENST00000382103.7 [Q9HD40-1] Q9HD40 H0Y9D2 A0A7P0Z4P3 ENST00000503150.1 ENST00000358971.7 A1A4F3 J3KP25 ENST00000514585.5 [Q9HD40-2]

SEPSECS report