SENP3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SENP3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SENP3 at tissue level.

III. Associated gene sets

GO_0016926Biological processprotein desumoylation
GO_0006508Biological processproteolysis
GO_2000042Biological processnegative regulation of double-strand break repair via homologous recombination
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0071339Cellular componentMLL1 complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0016929Molecular functiondeSUMOylase activity
GO_0008234Molecular functioncysteine-type peptidase activity
GO_0005515Molecular functionprotein binding
GO_0004843Molecular functioncysteine-type deubiquitinase activity

IV. Literature review

[source]
Gene nameSENP3
Protein nameSUMO specific peptidase 3
Sentrin-specific protease 3 (EC 3.4.22.-) (SUMO-1-specific protease 3) (Sentrin/SUMO-specific protease SENP3)
SynonymsSUSP3
SSP3
DescriptionFUNCTION: Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates . Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability . Deconjugates SUMO2 and SUMO3 from CDCA8 . Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300 . Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 . Plays a role in the regulation of sumoylation status of ZNF148 . Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes . Deconjugates SUMO2 from KAT5 . .

AccessionsJ3QRE4
ENST00000321337.12
ENST00000610454.4
ENST00000582789.5
ENST00000581093.1
A0A087WV50
J3QL36
Q9H4L4
ENST00000619785.1
J3KSF5
A0A087WZ63
ENST00000580231.5