I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 5 studies | 20% ± 4% | |
| extravillous trophoblast | 3 studies | 20% ± 1% | |
| epithelial cell | 3 studies | 19% ± 4% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 5 studies | 20% ± 4% | |
| extravillous trophoblast | 3 studies | 20% ± 1% | |
| epithelial cell | 3 studies | 19% ± 4% |
Insufficient scRNA-seq data for expression of SEMA4C at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| ovary | 100% | 5322.71 | 180 / 180 | 100% | 40.01 | 428 / 430 |
| skin | 100% | 2988.37 | 1808 / 1809 | 100% | 65.97 | 470 / 472 |
| prostate | 100% | 6078.45 | 245 / 245 | 99% | 31.51 | 497 / 502 |
| breast | 100% | 4644.34 | 459 / 459 | 99% | 40.51 | 1106 / 1118 |
| uterus | 100% | 8722.52 | 170 / 170 | 98% | 40.24 | 451 / 459 |
| lung | 100% | 3994.66 | 577 / 578 | 98% | 37.22 | 1130 / 1155 |
| bladder | 100% | 6933.52 | 21 / 21 | 97% | 32.94 | 489 / 504 |
| brain | 97% | 3403.07 | 2573 / 2642 | 99% | 33.69 | 700 / 705 |
| esophagus | 100% | 5255.17 | 1443 / 1445 | 96% | 28.58 | 176 / 183 |
| thymus | 100% | 3585.40 | 651 / 653 | 95% | 28.65 | 577 / 605 |
| intestine | 100% | 6393.35 | 963 / 966 | 94% | 22.74 | 494 / 527 |
| stomach | 99% | 2973.54 | 357 / 359 | 91% | 21.24 | 261 / 286 |
| kidney | 99% | 2963.30 | 88 / 89 | 86% | 20.72 | 775 / 901 |
| adrenal gland | 100% | 2221.78 | 257 / 258 | 77% | 19.66 | 178 / 230 |
| liver | 100% | 2006.95 | 225 / 226 | 77% | 13.55 | 314 / 406 |
| pancreas | 69% | 927.83 | 227 / 328 | 97% | 29.59 | 173 / 178 |
| spleen | 100% | 8204.45 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 34.86 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 12.14 | 1 / 1 |
| blood vessel | 100% | 4619.18 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 100% | 4359.76 | 1203 / 1204 | 0% | 0 | 0 / 0 |
| heart | 99% | 2738.55 | 855 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 99% | 33.51 | 79 / 80 |
| muscle | 57% | 710.63 | 460 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 41% | 5.56 | 12 / 29 |
| peripheral blood | 40% | 800.35 | 374 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0021549 | Biological process | cerebellum development |
| GO_0071526 | Biological process | semaphorin-plexin signaling pathway |
| GO_0030335 | Biological process | positive regulation of cell migration |
| GO_0032874 | Biological process | positive regulation of stress-activated MAPK cascade |
| GO_0021535 | Biological process | cell migration in hindbrain |
| GO_0001755 | Biological process | neural crest cell migration |
| GO_0001843 | Biological process | neural tube closure |
| GO_0007411 | Biological process | axon guidance |
| GO_0050919 | Biological process | negative chemotaxis |
| GO_0042692 | Biological process | muscle cell differentiation |
| GO_0014069 | Cellular component | postsynaptic density |
| GO_0005615 | Cellular component | extracellular space |
| GO_0098839 | Cellular component | postsynaptic density membrane |
| GO_0030672 | Cellular component | synaptic vesicle membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0045499 | Molecular function | chemorepellent activity |
| GO_0030215 | Molecular function | semaphorin receptor binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | SEMA4C |
| Protein name | Semaphorin 4C SEMA4C protein Semaphorin-4C Uncharacterized protein SEMA4C |
| Synonyms | UNQ5855/PRO34487 KIAA1739 SEMAI |
| Description | FUNCTION: Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade. . |
| Accessions | ENST00000449330.1 ENST00000305476.10 C9J4M7 Q53RE7 Q9C0C4 C9JV89 ENST00000442264.5 Q6P5A5 |
