SEH1L report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006999Biological processnuclear pore organization
GO_0051028Biological processmRNA transport
GO_0051315Biological processattachment of mitotic spindle microtubules to kinetochore
GO_0051301Biological processcell division
GO_0031669Biological processcellular response to nutrient levels
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0034198Biological processcellular response to amino acid starvation
GO_0006913Biological processnucleocytoplasmic transport
GO_0015031Biological processprotein transport
GO_1904263Biological processpositive regulation of TORC1 signaling
GO_0007080Biological processmitotic metaphase chromosome alignment
GO_1904262Biological processnegative regulation of TORC1 signaling
GO_0031503Biological processprotein-containing complex localization
GO_0005643Cellular componentnuclear pore
GO_0000776Cellular componentkinetochore
GO_0061700Cellular componentGATOR2 complex
GO_0035859Cellular componentSeh1-associated complex
GO_0005635Cellular componentnuclear envelope
GO_0005829Cellular componentcytosol
GO_0031080Cellular componentnuclear pore outer ring
GO_0005765Cellular componentlysosomal membrane
GO_0005198Molecular functionstructural molecule activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSEH1L
Protein nameNucleoporin SEH1 (GATOR2 complex protein SEH1) (Nup107-160 subcomplex subunit SEH1) (SEC13-like protein)
SEH1 like nucleoporin
SynonymsSEC13L
SEH1
DescriptionFUNCTION: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC . The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore . .; FUNCTION: As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway . The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex . GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1 . In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation . In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex . Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex . .

AccessionsK7EPZ5
ENST00000399892.7 [Q96EE3-1]
ENST00000587761.1
ENST00000589446.5
Q96EE3
ENST00000585730.5
K7ELV2
ENST00000262124.15 [Q96EE3-2]
ENST00000592170.5
K7ENI5
K7EP88