SEC16A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0072659Biological processprotein localization to plasma membrane
GO_0032527Biological processprotein exit from endoplasmic reticulum
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0003400Biological processregulation of COPII vesicle coating
GO_0007029Biological processendoplasmic reticulum organization
GO_0070973Biological processprotein localization to endoplasmic reticulum exit site
GO_0007030Biological processGolgi organization
GO_0050821Biological processprotein stabilization
GO_0006893Biological processGolgi to plasma membrane transport
GO_0021762Biological processsubstantia nigra development
GO_0006914Biological processautophagy
GO_0006888Biological processendoplasmic reticulum to Golgi vesicle-mediated transport
GO_0048208Biological processCOPII vesicle coating
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0070971Cellular componentendoplasmic reticulum exit site
GO_0000139Cellular componentGolgi membrane
GO_0005829Cellular componentcytosol
GO_0012507Cellular componentER to Golgi transport vesicle membrane
GO_0031090Cellular componentorganelle membrane
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSEC16A
Protein nameSEC16 homolog A, endoplasmic reticulum export factor (cDNA FLJ37437 fis, clone BRAWH2003025)
Protein transport protein sec16
SEC16A protein
Protein transport protein Sec16A (SEC16 homolog A) (p250)
SEC16 homolog A, endoplasmic reticulum export factor
Protein transport protein Sec16A
SynonymsKIAA0310
SEC16L
SEC16
DescriptionFUNCTION: Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus . Mediates the recruitment of MIA3/TANGO to ERES . Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane . Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183 . Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By similarity). .

FUNCTION: Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. .

FUNCTION: Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. .

FUNCTION: Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. .

FUNCTION: Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. .

FUNCTION: Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. .

FUNCTION: Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. .

FUNCTION: Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. .

AccessionsA0PJ75
O15027
A4QN18
X6RGP5
ENST00000313084.9
ENST00000690691.1
ENST00000689049.1
ENST00000684901.1 [O15027-1]
ENST00000290037.10
F1T0I1
ENST00000371706.8
A0A8I5KPG1
A0A0C4DH09
A0A3F2YNX0
ENST00000313050.11 [O15027-1]
A0A8I5KQ88
A4QN19
G1UI25
Q8N9G1
ENST00000453963.5
Q9BV84
ENST00000277537.10
ENST00000431893.3
A0A3F2YNZ0