SEC14L2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0045540Biological processregulation of cholesterol biosynthetic process
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0008431Molecular functionvitamin E binding
GO_0005543Molecular functionphospholipid binding

IV. Literature review

[source]
Gene nameSEC14L2
Protein nameSEC14 like lipid binding 2
SEC14-like protein 2 (Alpha-tocopherol-associated protein) (TAP) (hTAP) (Squalene transfer protein) (Supernatant protein factor) (SPF)
SEC14 like lipid binding 2 (SEC14-like 2 (S. cerevisiae), isoform CRA_c) (cDNA FLJ34083 fis, clone FCBBF3004409, highly similar to SEC14-like protein 2)
SynonymsC22orf6
KIAA1186
hCG_41297
KIAA1658
DescriptionFUNCTION: Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell.

AccessionsENST00000402592.7 [O76054-5]
ENST00000437022.5
ENST00000415072.1
ENST00000452649.1
C9JZI9
F8WED8
ENST00000617837.4
C9JYY7
ENST00000429917.5
ENST00000428195.5
F8WEE7
B3KRD8
ENST00000405717.7 [O76054-4]
C9JTM4
ENST00000615189.5 [O76054-1]
O76054