I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| macrophage | 8 studies | 23% ± 8% | |
| hepatocyte | 5 studies | 51% ± 25% | |
| myeloid cell | 4 studies | 27% ± 12% | |
| leukocyte | 3 studies | 18% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| macrophage | 8 studies | 23% ± 8% | |
| hepatocyte | 5 studies | 51% ± 25% | |
| myeloid cell | 4 studies | 27% ± 12% | |
| leukocyte | 3 studies | 18% ± 3% |
Insufficient scRNA-seq data for expression of SDS at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 38712.10 | 226 / 226 | 87% | 417.74 | 353 / 406 |
| brain | 96% | 1131.35 | 2527 / 2642 | 90% | 14.45 | 637 / 705 |
| lung | 80% | 466.80 | 462 / 578 | 86% | 12.53 | 993 / 1155 |
| breast | 38% | 125.06 | 176 / 459 | 94% | 14.91 | 1049 / 1118 |
| adrenal gland | 88% | 610.32 | 227 / 258 | 32% | 5.17 | 73 / 230 |
| intestine | 37% | 124.13 | 362 / 966 | 74% | 8.80 | 391 / 527 |
| stomach | 19% | 66.87 | 68 / 359 | 84% | 10.70 | 240 / 286 |
| ovary | 13% | 22.01 | 23 / 180 | 85% | 10.20 | 365 / 430 |
| kidney | 12% | 17.85 | 11 / 89 | 83% | 15.20 | 745 / 901 |
| pancreas | 12% | 27.69 | 40 / 328 | 83% | 13.83 | 147 / 178 |
| prostate | 32% | 70.56 | 79 / 245 | 55% | 4.11 | 278 / 502 |
| uterus | 6% | 9.94 | 11 / 170 | 77% | 8.53 | 354 / 459 |
| esophagus | 5% | 27.03 | 73 / 1445 | 74% | 8.43 | 135 / 183 |
| tonsil | 0% | 0 | 0 / 0 | 71% | 6.28 | 32 / 45 |
| skin | 1% | 2.26 | 25 / 1809 | 65% | 7.70 | 307 / 472 |
| bladder | 0% | 0 | 0 / 21 | 66% | 8.00 | 332 / 504 |
| thymus | 31% | 65.79 | 204 / 653 | 26% | 1.78 | 159 / 605 |
| adipose | 47% | 243.45 | 566 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 45% | 3.32 | 13 / 29 |
| peripheral blood | 35% | 155.87 | 327 / 929 | 0% | 0 | 0 / 0 |
| blood vessel | 32% | 201.04 | 423 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 30% | 115.99 | 72 / 241 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 25% | 2.01 | 20 / 80 |
| heart | 13% | 30.14 | 111 / 861 | 0% | 0 | 0 / 0 |
| muscle | 6% | 22.96 | 48 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0042866 | Biological process | pyruvate biosynthetic process |
| GO_0006565 | Biological process | L-serine catabolic process |
| GO_0006629 | Biological process | lipid metabolic process |
| GO_0006094 | Biological process | gluconeogenesis |
| GO_0009097 | Biological process | isoleucine biosynthetic process |
| GO_0006567 | Biological process | threonine catabolic process |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0005829 | Cellular component | cytosol |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0004794 | Molecular function | threonine deaminase activity |
| GO_0030170 | Molecular function | pyridoxal phosphate binding |
| GO_0003941 | Molecular function | L-serine ammonia-lyase activity |
| Gene name | SDS |
| Protein name | L-serine ammonia-lyase (EC 4.3.1.17) (L-serine deaminase) (L-threonine dehydratase) L-serine dehydratase/L-threonine deaminase (SDH) (EC 4.3.1.17) (L-serine deaminase) (L-threonine dehydratase) (TDH) (EC 4.3.1.19) |
| Synonyms | SDH |
| Description | |
| Accessions | ENST00000552280.5 ENST00000547342.1 P20132 ENST00000257549.9 F8VXS0 F8VW93 |
