SDHAF3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0034553Biological processmitochondrial respiratory chain complex II assembly
GO_0006105Biological processsuccinate metabolic process
GO_0006111Biological processregulation of gluconeogenesis
GO_0005758Cellular componentmitochondrial intermembrane space
GO_0005759Cellular componentmitochondrial matrix

IV. Literature review

[source]
Gene nameSDHAF3
Protein nameSuccinate dehydrogenase assembly factor 3 (SDH assembly factor 3) (SDHAF3)
Succinate dehydrogenase assembly factor 3, mitochondrial (SDH assembly factor 3) (SDHAF3)
SynonymsACN9
DC11
DescriptionFUNCTION: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1. .

FUNCTION: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1. .

AccessionsENST00000360382.4
Q9NRP4
ENST00000432641.3
F8W9V1