SDE2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SDE2 at tissue level.

III. Associated gene sets

GO_0000479Biological processendonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO_0016567Biological processprotein ubiquitination
GO_0016485Biological processprotein processing
GO_0031571Biological processmitotic G1 DNA damage checkpoint signaling
GO_0051301Biological processcell division
GO_0006260Biological processDNA replication
GO_0034644Biological processcellular response to UV
GO_0045292Biological processmRNA cis splicing, via spliceosome
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005794Cellular componentGolgi apparatus
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0030515Molecular functionsnoRNA binding
GO_0005515Molecular functionprotein binding
GO_0003684Molecular functiondamaged DNA binding

IV. Literature review

[source]
Gene nameSDE2
Protein nameSplicing regulator SDE2 (Replication stress response regulator SDE2)
SynonymsC1orf55
DescriptionFUNCTION: Inhibits translesion DNA synthesis by preventing monoubiquitination of PCNA, this is necessary to counteract damage due to ultraviolet light-induced replication stress . SDE2 is cleaved following PCNA binding, and its complete degradation is necessary to allow S-phase progression following DNA damage . .; FUNCTION: Plays a role in pre-mRNA splicing by facilitating excision of relatively short introns featuring weak 3'-splice sites (ss) and high GC content . May recruit CACTIN to the spliceosome (By similarity). .; FUNCTION: Plays a role in ribosome biogenesis by enabling SNORD3- and SNORD118-dependent cleavage of the 47S rRNA precursor . Binds ncRNA (non-coding RNA) including the snoRNAs SNORD3 and SNORD118 . .

AccessionsQ6IQ49
ENST00000272091.8 [Q6IQ49-1]