SCN4A report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SCN4A at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SCN4A at tissue level.

III. Associated gene sets

GO_0100001Biological processregulation of skeletal muscle contraction by action potential
GO_0006936Biological processmuscle contraction
GO_0086002Biological processcardiac muscle cell action potential involved in contraction
GO_0006814Biological processsodium ion transport
GO_0035725Biological processsodium ion transmembrane transport
GO_0001518Cellular componentvoltage-gated sodium channel complex
GO_0005886Cellular componentplasma membrane
GO_0005248Molecular functionvoltage-gated sodium channel activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSCN4A
Protein nameType IV sodium channel alpha polypeptide
Sodium channel protein type 4 subunit alpha (SkM1) (Sodium channel protein skeletal muscle subunit alpha) (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4)
Sodium channel alpha-subunit
Synonyms
DescriptionFUNCTION: Pore-forming subunit of a voltage-gated sodium channel complex through which Na(+) ions pass in accordance with their electrochemical gradient. Alternates between resting, activated and inactivated states . Required for normal muscle fiber excitability, normal muscle contraction and relaxation cycles, and constant muscle strength in the presence of fluctuating K(+) levels . .

AccessionsP35499
Q9H3L9
ENST00000435607.3
O60217