SCN3A | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
oligodendrocyte precursor cell	15 studies	51% ± 18%	Explore
GABAergic neuron	11 studies	53% ± 22%	Explore
glutamatergic neuron	11 studies	65% ± 20%	Explore
interneuron	6 studies	64% ± 16%	Explore
neuron	5 studies	44% ± 19%	Explore
pericyte	5 studies	28% ± 15%	Explore
endothelial cell of lymphatic vessel	5 studies	26% ± 8%	Explore
granule cell	4 studies	40% ± 18%	Explore
GABAergic interneuron	3 studies	55% ± 9%	Explore
astrocyte	3 studies	26% ± 10%	Explore
smooth muscle cell	3 studies	27% ± 6%	Explore
GABAergic amacrine cell	3 studies	36% ± 15%	Explore
retinal cone cell	3 studies	46% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	15 studies	40% ± 22%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	99%	1902.30	2628 / 2642	97%	23.25	684 / 705
thymus	92%	398.56	602 / 653	14%	0.45	84 / 605
kidney	82%	338.52	73 / 89	5%	0.21	49 / 901
breast	81%	297.32	372 / 459	5%	0.13	59 / 1118
adipose	86%	401.35	1038 / 1204	0%	0	0 / 0
adrenal gland	19%	63.60	49 / 258	64%	10.10	147 / 230
blood vessel	80%	397.11	1074 / 1335	0%	0	0 / 0
uterus	67%	218.65	114 / 170	6%	0.45	28 / 459
intestine	63%	200.47	606 / 966	4%	0.06	19 / 527
spleen	57%	163.44	137 / 241	0%	0	0 / 0
esophagus	46%	123.32	663 / 1445	8%	0.27	15 / 183
bladder	48%	124.00	10 / 21	4%	0.39	19 / 504
heart	50%	144.59	433 / 861	0%	0	0 / 0
ovary	46%	179.91	83 / 180	1%	0.02	4 / 430
stomach	32%	73.64	114 / 359	5%	0.36	13 / 286
lung	12%	27.62	70 / 578	8%	0.89	97 / 1155
muscle	19%	43.23	151 / 803	0%	0	0 / 0
skin	13%	33.75	237 / 1809	4%	0.11	21 / 472
pancreas	3%	7.17	11 / 328	11%	0.25	20 / 178
prostate	11%	39.29	27 / 245	1%	0.01	4 / 502
lymph node	0%	0	0 / 0	3%	0.29	1 / 29
peripheral blood	3%	15.13	30 / 929	0%	0	0 / 0
liver	0%	0	0 / 226	1%	0.05	3 / 406
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0048266	Biological process	behavioral response to pain
GO_0086002	Biological process	cardiac muscle cell action potential involved in contraction
GO_0006814	Biological process	sodium ion transport
GO_0035725	Biological process	sodium ion transmembrane transport
GO_0001518	Cellular component	voltage-gated sodium channel complex
GO_0016528	Cellular component	sarcoplasm
GO_0005248	Molecular function	voltage-gated sodium channel activity

IV. Literature review

[source]

Gene name	SCN3A
Protein name	SCN3A (Voltage-gated sodium channel) Alternative protein SCN3A Sodium channel protein type 3 subunit alpha (Sodium channel protein brain III subunit alpha) (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subtype III) (Voltage-gated sodium channel subunit alpha Nav1.3) Sodium channel protein Sodium voltage-gated channel alpha subunit 3
Synonyms	KIAA1356 NAC3
Description	FUNCTION: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient . May contribute to the regulation of serotonin/5-hydroxytryptamine release by enterochromaffin cells (By similarity). In pancreatic endocrine cells, required for both glucagon and glucose-induced insulin secretion (By similarity). . FUNCTION: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. . FUNCTION: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. . FUNCTION: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. .
Accessions	A0A1W2PRD1 A0A994J5P2 A0A590UJW3 Q9NY46 A0A1W2PSB2 ENST00000658209.1 ENST00000283254.12 [Q9NY46-3] ENST00000638473.1 A0A1W2PQ58 ENST00000409101.7 [Q9NY46-2] Q9GZM4 ENST00000453007.1 C9JBM7 E7EUE6 ENST00000668657.1 ENST00000640652.1 L8E9G6 A0A590UJH3 ENST00000440431.6 ENST00000706067.1 ENST00000639244.1 Q9C007

SCN3A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review