SCN10A report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SCN10A at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SCN10A at tissue level.

III. Associated gene sets

GO_0042475Biological processodontogenesis of dentin-containing tooth
GO_0086002Biological processcardiac muscle cell action potential involved in contraction
GO_0086016Biological processAV node cell action potential
GO_0002027Biological processregulation of heart rate
GO_0007600Biological processsensory perception
GO_0099505Biological processregulation of presynaptic membrane potential
GO_0034765Biological processregulation of monoatomic ion transmembrane transport
GO_0086043Biological processbundle of His cell action potential
GO_0060371Biological processregulation of atrial cardiac muscle cell membrane depolarization
GO_0086010Biological processmembrane depolarization during action potential
GO_0055117Biological processregulation of cardiac muscle contraction
GO_0035725Biological processsodium ion transmembrane transport
GO_0098978Cellular componentglutamatergic synapse
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0071439Cellular componentclathrin complex
GO_0042734Cellular componentpresynaptic membrane
GO_0001518Cellular componentvoltage-gated sodium channel complex
GO_0030424Cellular componentaxon
GO_0005248Molecular functionvoltage-gated sodium channel activity
GO_0099508Molecular functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
GO_0044325Molecular functiontransmembrane transporter binding

IV. Literature review

[source]
Gene nameSCN10A
Protein nameSodium channel protein type 10 subunit alpha (Peripheral nerve sodium channel 3) (PN3) (hPN3) (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8)
Sodium channel protein
Synonyms
DescriptionFUNCTION: Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms. .

FUNCTION: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. .; FUNCTION: Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms. .

FUNCTION: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. .; FUNCTION: Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms. .

AccessionsA0A590UJM0
Q9Y5Y9
A0A2R8Y6J6
ENST00000655275.1
ENST00000449082.3
ENST00000643924.1