SCG5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016486Biological processpeptide hormone processing
GO_0046883Biological processregulation of hormone secretion
GO_0007218Biological processneuropeptide signaling pathway
GO_0006886Biological processintracellular protein transport
GO_0030141Cellular componentsecretory granule
GO_0005576Cellular componentextracellular region
GO_0005634Cellular componentnucleus
GO_0005525Molecular functionGTP binding
GO_0004857Molecular functionenzyme inhibitor activity
GO_0030234Molecular functionenzyme regulator activity
GO_0005515Molecular functionprotein binding
GO_0051082Molecular functionunfolded protein binding

IV. Literature review

[source]
Gene nameSCG5
Protein nameNeuroendocrine protein 7B2 (Secretogranin-5)
Neuroendocrine protein 7B2 (Pituitary polypeptide) (Secretogranin V) (Secretogranin-5) (Secretory granule endocrine protein I) [Cleaved into: N-terminal peptide; C-terminal peptide]
SynonymsSGNE1
DescriptionFUNCTION: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. .

FUNCTION: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. .

FUNCTION: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. .

FUNCTION: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. .

AccessionsH7C4X7
ENST00000471027.1
ENST00000633221.1
ENST00000632674.1 [P05408-2]
ENST00000494364.5
C9JNY7
ENST00000413748.6 [P05408-2]
C9J650
ENST00000633420.1
ENST00000300175.9 [P05408-1]
ENST00000497208.5
ENST00000632955.1
ENST00000632219.1 [P05408-1]
P05408
ENST00000614359.1 [P05408-1]