Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 10 studies | 25% ± 8% | |
oligodendrocyte | 9 studies | 23% ± 8% | |
glutamatergic neuron | 7 studies | 38% ± 24% | |
microglial cell | 6 studies | 24% ± 7% | |
fibroblast | 5 studies | 20% ± 8% | |
adipocyte | 5 studies | 20% ± 4% | |
oligodendrocyte precursor cell | 5 studies | 28% ± 9% | |
macrophage | 5 studies | 22% ± 6% | |
myeloid cell | 4 studies | 19% ± 2% | |
epithelial cell | 4 studies | 28% ± 7% | |
astrocyte | 4 studies | 31% ± 7% | |
monocyte | 4 studies | 20% ± 2% | |
interneuron | 4 studies | 34% ± 20% | |
B cell | 3 studies | 18% ± 3% | |
classical monocyte | 3 studies | 22% ± 6% | |
neuron | 3 studies | 27% ± 11% | |
GABAergic neuron | 3 studies | 49% ± 5% | |
dendritic cell | 3 studies | 26% ± 11% | |
cardiac muscle cell | 3 studies | 17% ± 3% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 9 studies | 31% ± 17% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 4391.63 | 2642 / 2642 | 100% | 55.26 | 705 / 705 |
esophagus | 100% | 3142.62 | 1445 / 1445 | 100% | 23.96 | 183 / 183 |
lung | 100% | 3382.66 | 578 / 578 | 100% | 16.54 | 1150 / 1155 |
breast | 100% | 3665.20 | 459 / 459 | 99% | 21.40 | 1106 / 1118 |
thymus | 100% | 2150.61 | 652 / 653 | 99% | 16.23 | 597 / 605 |
prostate | 100% | 2394.13 | 244 / 245 | 99% | 13.47 | 495 / 502 |
uterus | 100% | 3552.31 | 170 / 170 | 97% | 15.75 | 444 / 459 |
adrenal gland | 100% | 2688.43 | 258 / 258 | 97% | 17.46 | 222 / 230 |
bladder | 100% | 2997.86 | 21 / 21 | 95% | 12.12 | 479 / 504 |
kidney | 100% | 1384.37 | 89 / 89 | 94% | 13.19 | 847 / 901 |
intestine | 100% | 2193.79 | 966 / 966 | 91% | 9.60 | 481 / 527 |
skin | 100% | 2687.96 | 1805 / 1809 | 89% | 11.52 | 421 / 472 |
stomach | 96% | 1518.51 | 346 / 359 | 92% | 10.36 | 264 / 286 |
ovary | 100% | 3928.78 | 180 / 180 | 88% | 6.76 | 377 / 430 |
pancreas | 85% | 767.21 | 280 / 328 | 97% | 15.21 | 173 / 178 |
liver | 80% | 717.69 | 181 / 226 | 59% | 4.46 | 241 / 406 |
adipose | 100% | 4063.47 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 2967.18 | 1335 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 5266.74 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 2020.67 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 15.48 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 4.98 | 1 / 1 |
lymph node | 0% | 0 | 0 / 0 | 97% | 9.33 | 28 / 29 |
heart | 96% | 2118.85 | 830 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 93% | 2259.33 | 863 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 51% | 4.83 | 41 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_2000303 | Biological process | regulation of ceramide biosynthetic process |
GO_0006686 | Biological process | sphingomyelin biosynthetic process |
GO_1905373 | Biological process | ceramide phosphoethanolamine biosynthetic process |
GO_0046513 | Biological process | ceramide biosynthetic process |
GO_0000139 | Cellular component | Golgi membrane |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0005829 | Cellular component | cytosol |
GO_0005886 | Cellular component | plasma membrane |
GO_0016020 | Cellular component | membrane |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0047493 | Molecular function | ceramide cholinephosphotransferase activity |
GO_0002950 | Molecular function | ceramide phosphoethanolamine synthase activity |
GO_0033188 | Molecular function | sphingomyelin synthase activity |
GO_0003674 | Molecular function | molecular_function |
Gene name | SAMD8 |
Protein name | Sphingomyelin synthase-related protein 1 (SMSr) (EC 2.7.8.-) (Ceramide phosphoethanolamine synthase) (CPE synthase) (Sterile alpha motif domain-containing protein 8) (SAM domain-containing protein 8) Sterile alpha motif domain containing 8 |
Synonyms | |
Description | FUNCTION: Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway. . |
Accessions | ENST00000649316.2 ENST00000671800.1 [Q96LT4-1] Q5JSC9 A0A5F9ZGS6 ENST00000671730.1 ENST00000542569.6 [Q96LT4-1] A0A3B3IT94 Q96LT4 ENST00000372687.4 [Q96LT4-2] ENST00000447533.5 |