S100A1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1903672Biological processpositive regulation of sprouting angiogenesis
GO_0035556Biological processintracellular signal transduction
GO_0021762Biological processsubstantia nigra development
GO_0051000Biological processpositive regulation of nitric-oxide synthase activity
GO_0008016Biological processregulation of heart contraction
GO_0005576Cellular componentextracellular region
GO_0005739Cellular componentmitochondrion
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0005829Cellular componentcytosol
GO_0016529Cellular componentsarcoplasmic reticulum
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0042802Molecular functionidentical protein binding
GO_0048306Molecular functioncalcium-dependent protein binding
GO_0051117Molecular functionATPase binding
GO_0044548Molecular functionS100 protein binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameS100A1
Protein nameProtein S100-A1 (S-100 protein alpha chain) (S-100 protein subunit alpha) (S100 calcium-binding protein A1)
S100 calcium binding protein A1
Protein S100 (S100 calcium-binding protein)
SynonymshCG_15470
S100A
DescriptionFUNCTION: Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation . In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes . These changes allow interactions with specific target proteins and modulate their activity . Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase . Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole . .

AccessionsENST00000368696.3
Q5T7Y4
Q5T7Y6
ENST00000436839.1
ENST00000368698.3
P23297
A0A0S2Z4H2
ENST00000292169.6
Q5T7Y5