RWDD3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of RWDD3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RWDD3 at tissue level.

III. Associated gene sets

GO_0033235Biological processpositive regulation of protein sumoylation
GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_1902073Biological processpositive regulation of hypoxia-inducible factor-1alpha signaling pathway
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRWDD3
Protein nameRWD domain-containing protein 3 (RWD domain-containing sumoylation enhancer) (RSUME)
SynonymsRSUME
DescriptionFUNCTION: Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1. Isoform 1 and isoform 2 positively regulate the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha (NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity. Isoform 1 and isoform 2 negatively regulate the hypoxia-inducible factor-1 alpha (HIF1A) signaling pathway by increasing the sumoylation of HIF1A, promoting its stabilization, transcriptional activity and the expression of its target gene VEGFA during hypoxia. Isoform 2 promotes the sumoylation and transcriptional activity of the glucocorticoid receptor NR3C1 and enhances the interaction of SUMO1 and NR3C1 with UBE2I/UBC9. Has no effect on ubiquitination. .

AccessionsENST00000263893.10 [Q9Y3V2-2]
Q9Y3V2
ENST00000370202.5 [Q9Y3V2-1]