RUFY4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of RUFY4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RUFY4 at tissue level.

III. Associated gene sets

GO_0016239Biological processpositive regulation of macroautophagy
GO_0071353Biological processcellular response to interleukin-4
GO_0000045Biological processautophagosome assembly
GO_0031410Cellular componentcytoplasmic vesicle
GO_0005776Cellular componentautophagosome
GO_0032266Molecular functionphosphatidylinositol-3-phosphate binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameRUFY4
Protein nameRUN and FYVE domain-containing protein 4
RUN and FYVE domain containing 4
Synonyms
DescriptionFUNCTION: Positively regulates macroautophagy in primary dendritic cells. Increases autophagic flux, probably by stimulating both autophagosome formation and facilitating tethering with lysosomes. Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through its FYVE-type zinc finger. .

AccessionsQ6ZNE9
C9J235
ENST00000374155.7
ENST00000457754.6 [Q6ZNE9-3]
ENST00000697321.1 [Q6ZNE9-2]
ENST00000344321.8 [Q6ZNE9-2]