I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 5 studies | 21% ± 3% | |
| ciliated cell | 4 studies | 25% ± 6% | |
| GABAergic neuron | 3 studies | 28% ± 4% | |
| glutamatergic neuron | 3 studies | 33% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 5 studies | 21% ± 3% | |
| ciliated cell | 4 studies | 25% ± 6% | |
| GABAergic neuron | 3 studies | 28% ± 4% | |
| glutamatergic neuron | 3 studies | 33% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 22% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 1702.96 | 2637 / 2642 | 100% | 36.29 | 703 / 705 |
| esophagus | 100% | 1507.19 | 1444 / 1445 | 99% | 26.48 | 182 / 183 |
| prostate | 100% | 1963.23 | 245 / 245 | 99% | 31.51 | 498 / 502 |
| kidney | 100% | 1697.00 | 89 / 89 | 99% | 44.92 | 892 / 901 |
| lung | 100% | 2535.00 | 577 / 578 | 99% | 31.17 | 1145 / 1155 |
| adrenal gland | 100% | 3302.98 | 258 / 258 | 99% | 33.65 | 227 / 230 |
| thymus | 100% | 3895.01 | 653 / 653 | 98% | 64.27 | 595 / 605 |
| breast | 100% | 1562.48 | 459 / 459 | 98% | 39.54 | 1099 / 1118 |
| uterus | 100% | 1495.34 | 170 / 170 | 96% | 21.02 | 441 / 459 |
| bladder | 100% | 1539.90 | 21 / 21 | 96% | 24.24 | 482 / 504 |
| pancreas | 98% | 978.55 | 320 / 328 | 98% | 21.35 | 174 / 178 |
| stomach | 100% | 1077.89 | 358 / 359 | 93% | 21.53 | 266 / 286 |
| intestine | 100% | 1584.69 | 966 / 966 | 93% | 19.14 | 488 / 527 |
| liver | 100% | 1113.23 | 226 / 226 | 91% | 17.30 | 370 / 406 |
| skin | 99% | 1868.37 | 1797 / 1809 | 92% | 30.44 | 433 / 472 |
| ovary | 100% | 1560.60 | 180 / 180 | 89% | 15.67 | 382 / 430 |
| muscle | 100% | 3997.09 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 1585.41 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 20.88 | 1 / 1 |
| blood vessel | 100% | 2140.37 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 100% | 1761.27 | 1202 / 1204 | 0% | 0 | 0 / 0 |
| heart | 98% | 1424.60 | 841 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 97% | 25.89 | 28 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 96% | 21.50 | 43 / 45 |
| peripheral blood | 78% | 1804.46 | 728 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 76% | 26.61 | 61 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0014075 | Biological process | response to amine |
| GO_0006281 | Biological process | DNA repair |
| GO_0010971 | Biological process | positive regulation of G2/M transition of mitotic cell cycle |
| GO_0003014 | Biological process | renal system process |
| GO_0006264 | Biological process | mitochondrial DNA replication |
| GO_0070318 | Biological process | positive regulation of G0 to G1 transition |
| GO_0001822 | Biological process | kidney development |
| GO_0009263 | Biological process | deoxyribonucleotide biosynthetic process |
| GO_0009185 | Biological process | ribonucleoside diphosphate metabolic process |
| GO_0009200 | Biological process | deoxyribonucleoside triphosphate metabolic process |
| GO_1902254 | Biological process | negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator |
| GO_0009265 | Biological process | 2'-deoxyribonucleotide biosynthetic process |
| GO_0000731 | Biological process | DNA synthesis involved in DNA repair |
| GO_0006979 | Biological process | response to oxidative stress |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005971 | Cellular component | ribonucleoside-diphosphate reductase complex |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0004748 | Molecular function | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| GO_0005515 | Molecular function | protein binding |
| Gene name | RRM2B |
| Protein name | Ribonucleotide reductase regulatory TP53 inducible subunit M2B Ribonucleoside-diphosphate reductase subunit M2 B (EC 1.17.4.1) (TP53-inducible ribonucleotide reductase M2 B) (p53-inducible ribonucleotide reductase small subunit 2-like protein) (p53R2) |
| Synonyms | P53R2 |
| Description | FUNCTION: Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. . |
| Accessions | ENST00000251810.8 [Q7LG56-1] ENST00000395912.6 [Q7LG56-2] H0YAV1 ENST00000522394.1 [Q7LG56-5] ENST00000519962.5 [Q7LG56-4] ENST00000519317.5 [Q7LG56-3] Q7LG56 E5RG52 ENST00000523957.1 ENST00000522368.5 |
