RRM1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
epithelial cell	5 studies	26% ± 8%	Explore
T cell	5 studies	22% ± 4%	Explore
CD4-positive, alpha-beta T cell	5 studies	28% ± 7%	Explore
hematopoietic precursor cell	4 studies	20% ± 3%	Explore
CD8-positive, alpha-beta T cell	4 studies	27% ± 2%	Explore
plasmablast	3 studies	36% ± 16%	Explore
basal cell	3 studies	20% ± 3%	Explore
pro-B cell	3 studies	29% ± 5%	Explore
GABAergic neuron	3 studies	24% ± 4%	Explore
glutamatergic neuron	3 studies	30% ± 6%	Explore
erythrocyte	3 studies	32% ± 17%	Explore
transit amplifying cell	3 studies	43% ± 13%	Explore
natural killer cell	3 studies	28% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	3 studies	21% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
stomach	100%	1867.77	359 / 359	100%	58.76	286 / 286
esophagus	100%	2667.23	1444 / 1445	100%	77.11	183 / 183
breast	100%	2125.85	459 / 459	100%	83.68	1116 / 1118
uterus	100%	1888.37	170 / 170	100%	95.28	457 / 459
lung	99%	1810.54	574 / 578	100%	63.63	1155 / 1155
intestine	100%	2157.52	966 / 966	99%	62.26	523 / 527
prostate	100%	1738.67	245 / 245	99%	43.42	497 / 502
bladder	100%	2142.33	21 / 21	98%	61.91	494 / 504
brain	97%	1290.41	2570 / 2642	99%	47.21	701 / 705
skin	100%	5591.14	1809 / 1809	97%	53.20	456 / 472
thymus	100%	1416.42	652 / 653	97%	42.31	585 / 605
ovary	100%	1869.03	180 / 180	96%	31.58	411 / 430
pancreas	96%	1084.87	316 / 328	99%	37.49	176 / 178
kidney	97%	1087.31	86 / 89	91%	29.12	818 / 901
adrenal gland	100%	3411.19	258 / 258	82%	26.23	189 / 230
liver	80%	697.56	180 / 226	85%	26.87	346 / 406
adipose	100%	2040.35	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	82.57	29 / 29
muscle	100%	2559.07	803 / 803	0%	0	0 / 0
spleen	100%	1622.34	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	125.03	45 / 45
ureter	0%	0	0 / 0	100%	25.19	1 / 1
blood vessel	100%	2383.08	1334 / 1335	0%	0	0 / 0
heart	90%	1270.93	776 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	78%	19.40	62 / 80
peripheral blood	57%	2662.40	533 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006281	Biological process	DNA repair
GO_0010971	Biological process	positive regulation of G2/M transition of mitotic cell cycle
GO_0021846	Biological process	cell proliferation in forebrain
GO_0006264	Biological process	mitochondrial DNA replication
GO_0010212	Biological process	response to ionizing radiation
GO_0070318	Biological process	positive regulation of G0 to G1 transition
GO_0060041	Biological process	retina development in camera-type eye
GO_0009263	Biological process	deoxyribonucleotide biosynthetic process
GO_1900087	Biological process	positive regulation of G1/S transition of mitotic cell cycle
GO_0009185	Biological process	ribonucleoside diphosphate metabolic process
GO_0009265	Biological process	2'-deoxyribonucleotide biosynthetic process
GO_0051290	Biological process	protein heterotetramerization
GO_0000731	Biological process	DNA synthesis involved in DNA repair
GO_0008584	Biological process	male gonad development
GO_0006206	Biological process	pyrimidine nucleobase metabolic process
GO_0005739	Cellular component	mitochondrion
GO_0043025	Cellular component	neuronal cell body
GO_0005635	Cellular component	nuclear envelope
GO_0005829	Cellular component	cytosol
GO_0042995	Cellular component	cell projection
GO_0005971	Cellular component	ribonucleoside-diphosphate reductase complex
GO_0061731	Molecular function	ribonucleoside-diphosphate reductase activity
GO_0042802	Molecular function	identical protein binding
GO_0005524	Molecular function	ATP binding
GO_0004748	Molecular function	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO_0097718	Molecular function	disordered domain specific binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	RRM1
Protein name	Ribonucleoside-diphosphate reductase (EC 1.17.4.1) Ribonucleotide reductase catalytic subunit M1 Ribonucleoside-diphosphate reductase large subunit (Ribonucleotide reductase large subunit) Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleoside-diphosphate reductase subunit M1) (Ribonucleotide reductase large subunit)
Synonyms	RR1
Description	FUNCTION: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. FUNCTION: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. .
Accessions	E9PP77 E9PRY9 ENST00000300738.10 E9PL69 E9PJ62 H0YCY7 ENST00000533349.5 ENST00000528442.5 P23921 ENST00000533495.5 ENST00000532170.5 ENST00000534285.5

RRM1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review