RRAGD report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1990253Biological processcellular response to leucine starvation
GO_0009267Biological processcellular response to starvation
GO_0071230Biological processcellular response to amino acid stimulus
GO_0010507Biological processnegative regulation of autophagy
GO_0008104Biological processprotein localization
GO_1904263Biological processpositive regulation of TORC1 signaling
GO_0032008Biological processpositive regulation of TOR signaling
GO_0071233Biological processcellular response to L-leucine
GO_0005813Cellular componentcentrosome
GO_0005764Cellular componentlysosome
GO_0005654Cellular componentnucleoplasm
GO_1990131Cellular componentGtr1-Gtr2 GTPase complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005765Cellular componentlysosomal membrane
GO_0005634Cellular componentnucleus
GO_0019003Molecular functionGDP binding
GO_0060090Molecular functionmolecular adaptor activity
GO_0051020Molecular functionGTPase binding
GO_0005525Molecular functionGTP binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameRRAGD
Protein nameRas-related GTP-binding protein D (Rag D) (RagD) (EC 3.6.5.-)
Synonyms
DescriptionFUNCTION: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade . Forms heterodimeric Rag complexes with RagA/RRAGA or RagB/RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form: RagD/RRAGD is in its active form when GDP-bound RagD/RRAGD forms a complex with GTP-bound RagA/RRAGA (or RagB/RRAGB) and in an inactive form when GTP-bound RagD/RRAGD heterodimerizes with GDP-bound RagA/RRAGA (or RagB/RRAGB) . In its active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB . This is a crucial step in the activation of the MTOR signaling cascade by amino acids . Also plays a central role in the non-canonical mTORC1 complex, which acts independently of RHEB and specifically mediates phosphorylation of MiT/TFE factors TFEB and TFE3: GDP-bound RagD/RRAGD mediates recruitment of MiT/TFE factors TFEB and TFE3 . .

AccessionsQ9NQL2
ENST00000369415.9 [Q9NQL2-1]
ENST00000359203.3 [Q9NQL2-2]