RRAGB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1990253Biological processcellular response to leucine starvation
GO_0009267Biological processcellular response to starvation
GO_0034198Biological processcellular response to amino acid starvation
GO_0071230Biological processcellular response to amino acid stimulus
GO_0010507Biological processnegative regulation of autophagy
GO_0008104Biological processprotein localization
GO_1904263Biological processpositive regulation of TORC1 signaling
GO_0032006Biological processregulation of TOR signaling
GO_0032008Biological processpositive regulation of TOR signaling
GO_0005764Cellular componentlysosome
GO_1990131Cellular componentGtr1-Gtr2 GTPase complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005765Cellular componentlysosomal membrane
GO_0005634Cellular componentnucleus
GO_0051020Molecular functionGTPase binding
GO_0005525Molecular functionGTP binding
GO_0032561Molecular functionguanyl ribonucleotide binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameRRAGB
Protein nameRas-related GTP-binding protein
Ras-related GTP-binding protein B (Rag B) (RagB) (EC 3.6.5.-)
Synonyms
DescriptionFUNCTION: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade . Forms heterodimeric Rag complexes with RagC/RRAGC or RagD/RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form: RagB/RRAGB is in its active form when GTP-bound RagB/RRAGB forms a complex with GDP-bound RagC/RRAGC (or RagD/RRAGD) and in an inactive form when GDP-bound RagB/RRAGB heterodimerizes with GTP-bound RagC/RRAGC (or RagD/RRAGD) . In its GTP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB . Involved in the RCC1/Ran-GTPase pathway . .

FUNCTION: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. .

AccessionsENST00000414239.5
Q5VZM2
ENST00000262850.7 [Q5VZM2-1]
ENST00000374941.9 [Q5VZM2-2]
Q5VZM0