RP2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RP2 at tissue level.

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0007601Biological processvisual perception
GO_0007023Biological processpost-chaperonin tubulin folding pathway
GO_0006892Biological processpost-Golgi vesicle-mediated transport
GO_0006457Biological processprotein folding
GO_0015031Biological processprotein transport
GO_1990075Cellular componentpericiliary membrane compartment
GO_0005886Cellular componentplasma membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0005814Cellular componentcentriole
GO_0005929Cellular componentcilium
GO_0016604Cellular componentnuclear body
GO_0005737Cellular componentcytoplasm
GO_0036064Cellular componentciliary basal body
GO_0000287Molecular functionmagnesium ion binding
GO_0005096Molecular functionGTPase activator activity
GO_0051082Molecular functionunfolded protein binding
GO_0005525Molecular functionGTP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRP2
Protein nameProtein XRP2
SynonymshCG_15708
DescriptionFUNCTION: Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as a guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins. .

FUNCTION: Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. .

AccessionsO75695
ENST00000218340.4
A0A1B2JLU2