RNLS report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071871Biological processresponse to epinephrine
GO_1902074Biological processresponse to salt
GO_0010459Biological processnegative regulation of heart rate
GO_0045776Biological processnegative regulation of blood pressure
GO_0002931Biological processresponse to ischemia
GO_0071869Biological processresponse to catecholamine
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0051379Molecular functionepinephrine binding
GO_0016651Molecular functionoxidoreductase activity, acting on NAD(P)H
GO_0005515Molecular functionprotein binding
GO_0097621Molecular functionmonoamine oxidase activity
GO_0070404Molecular functionNADH binding

IV. Literature review

[source]
Gene nameRNLS
Protein nameRenalase (EC 1.6.3.5) (Monoamine oxidase-C) (MAO-C)
SynonymsC10orf59
DescriptionFUNCTION: Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. .

AccessionsENST00000371947.7 [Q5VYX0-2]
ENST00000331772.9 [Q5VYX0-1]
Q5VYX0