RNF25 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of RNF25 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RNF25 at tissue level.

III. Associated gene sets

GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0160127Biological processprotein-RNA covalent cross-linking repair
GO_0016567Biological processprotein ubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0085020Biological processprotein K6-linked ubiquitination
GO_0072344Biological processrescue of stalled ribosome
GO_0022626Cellular componentcytosolic ribosome
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0051059Molecular functionNF-kappaB binding

IV. Literature review

[source]
Gene nameRNF25
Protein nameE3 ubiquitin-protein ligase RNF25 (EC 2.3.2.27) (RING finger protein 25) (RING finger protein AO7)
Ring finger protein 25
Synonyms
DescriptionFUNCTION: E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes . Catalyzes ubiquitination of RPS27A in response to ribosome collisions, promoting activation of RNF14 . RNF25 catalyzes ubiquitination of other ribosomal proteins on stalled ribosomes, such as RPL0, RPL1, RPL12, RPS13 and RPS17 . Also involved in ubiquitination and degradation of stalled ETF1/eRF1 . Independently of its function in the response to stalled ribosomes, mediates ubiquitination and subsequent proteasomal degradation of NKD2 (By similarity). May also stimulate transcription mediated by NF-kappa-B via its interaction with RELA/p65 . .

AccessionsQ96BH1
ENST00000423170.1
H7C219
ENST00000295704.7