Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 14 studies | 23% ± 8% | |
| fibroblast | 10 studies | 25% ± 8% | |
| adipocyte | 9 studies | 31% ± 9% | |
| oligodendrocyte | 9 studies | 26% ± 7% | |
| microglial cell | 7 studies | 24% ± 6% | |
| astrocyte | 7 studies | 36% ± 16% | |
| epithelial cell | 5 studies | 23% ± 4% | |
| GABAergic neuron | 5 studies | 43% ± 20% | |
| macrophage | 5 studies | 32% ± 7% | |
| endothelial cell of lymphatic vessel | 4 studies | 21% ± 5% | |
| smooth muscle cell | 4 studies | 18% ± 2% | |
| basal cell | 3 studies | 25% ± 7% | |
| club cell | 3 studies | 19% ± 4% | |
| hepatocyte | 3 studies | 42% ± 13% | |
| glutamatergic neuron | 3 studies | 64% ± 4% | |
| oligodendrocyte precursor cell | 3 studies | 24% ± 6% | |
| interneuron | 3 studies | 51% ± 21% | |
| neuron | 3 studies | 37% ± 15% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 7 studies | 37% ± 17% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 3327.04 | 653 / 653 | 94% | 6.84 | 571 / 605 |
| uterus | 100% | 2800.31 | 170 / 170 | 92% | 7.35 | 421 / 459 |
| ovary | 100% | 3936.58 | 180 / 180 | 88% | 4.40 | 377 / 430 |
| lung | 100% | 3603.62 | 578 / 578 | 86% | 8.23 | 990 / 1155 |
| kidney | 93% | 965.40 | 83 / 89 | 89% | 6.05 | 802 / 901 |
| prostate | 100% | 2219.30 | 244 / 245 | 80% | 2.94 | 403 / 502 |
| breast | 100% | 3197.00 | 459 / 459 | 76% | 4.32 | 854 / 1118 |
| pancreas | 90% | 824.29 | 294 / 328 | 84% | 4.27 | 149 / 178 |
| esophagus | 100% | 2520.69 | 1445 / 1445 | 73% | 12.31 | 134 / 183 |
| adrenal gland | 100% | 1492.04 | 258 / 258 | 71% | 3.73 | 164 / 230 |
| liver | 99% | 1513.03 | 223 / 226 | 69% | 3.16 | 282 / 406 |
| bladder | 100% | 2831.14 | 21 / 21 | 64% | 4.57 | 322 / 504 |
| brain | 83% | 713.81 | 2192 / 2642 | 80% | 2.82 | 562 / 705 |
| stomach | 100% | 1720.85 | 358 / 359 | 51% | 2.29 | 146 / 286 |
| intestine | 99% | 3080.68 | 958 / 966 | 49% | 2.27 | 260 / 527 |
| skin | 100% | 3242.04 | 1809 / 1809 | 46% | 1.86 | 216 / 472 |
| adipose | 100% | 3324.33 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 4344.19 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 99% | 1296.69 | 793 / 803 | 0% | 0 | 0 / 0 |
| spleen | 95% | 851.12 | 228 / 241 | 0% | 0 | 0 / 0 |
| heart | 92% | 1211.78 | 788 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 89% | 6.15 | 40 / 45 |
| peripheral blood | 5% | 33.17 | 47 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 5% | 0.12 | 4 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.08 | 1 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006511 | Biological process | ubiquitin-dependent protein catabolic process |
| GO_0000209 | Biological process | protein polyubiquitination |
| GO_0000151 | Cellular component | ubiquitin ligase complex |
| GO_0005829 | Cellular component | cytosol |
| GO_0016020 | Cellular component | membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0061630 | Molecular function | ubiquitin protein ligase activity |
| GO_0004842 | Molecular function | ubiquitin-protein transferase activity |
| GO_0008270 | Molecular function | zinc ion binding |
| GO_0031624 | Molecular function | ubiquitin conjugating enzyme binding |
| Gene name | RNF217 |
| Protein name | Ring finger protein 217 E3 ubiquitin-protein ligase RNF217 (EC 2.3.2.31) (IBR domain-containing protein 1) (Opposite STL) (RING finger protein 217) RBR-type E3 ubiquitin transferase (EC 2.3.2.31) |
| Synonyms | IBRDC1 OSTL C6orf172 |
| Description | FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the degradation of the iron exporter ferroportin/SLC40A1 and thus regulates iron homeostasis. . |
| Accessions | ENST00000519565.5 ENST00000432158.6 E5RFY6 ENST00000368414.6 H0YB95 Q8TC41 ENST00000359704.2 [Q8TC41-2] H0YKH8 ENST00000521654.7 [Q8TC41-1] H3BM17 ENST00000560949.5 |