RNF217 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0000209Biological processprotein polyubiquitination
GO_0000151Cellular componentubiquitin ligase complex
GO_0005829Cellular componentcytosol
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0008270Molecular functionzinc ion binding
GO_0031624Molecular functionubiquitin conjugating enzyme binding

IV. Literature review

[source]
Gene nameRNF217
Protein nameRing finger protein 217
E3 ubiquitin-protein ligase RNF217 (EC 2.3.2.31) (IBR domain-containing protein 1) (Opposite STL) (RING finger protein 217)
RBR-type E3 ubiquitin transferase (EC 2.3.2.31)
SynonymsIBRDC1
OSTL
C6orf172
DescriptionFUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the degradation of the iron exporter ferroportin/SLC40A1 and thus regulates iron homeostasis. .

AccessionsENST00000519565.5
ENST00000432158.6
E5RFY6
ENST00000368414.6
H0YB95
Q8TC41
ENST00000359704.2 [Q8TC41-2]
H0YKH8
ENST00000521654.7 [Q8TC41-1]
H3BM17
ENST00000560949.5