RNF170 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070936Biological processprotein K48-linked ubiquitination
GO_0034140Biological processnegative regulation of toll-like receptor 3 signaling pathway
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameRNF170
Protein nameE3 ubiquitin-protein ligase RNF170 (EC 2.3.2.27) (Putative LAG1-interacting protein) (RING finger protein 170) (RING-type E3 ubiquitin transferase RNF170)
Ring finger protein 170
Synonyms
DescriptionFUNCTION: E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells. Selectively inhibits the TLR3-triggered innate immune response by promoting the 'Lys-48'-linked polyubiquitination and degradation of TLR3 . .

AccessionsENST00000524954.1
ENST00000526349.5 [Q96K19-6]
E9PP55
ENST00000531440.5
ENST00000319073.5 [Q96K19-5]
Q96K19
E9PNG8
ENST00000527424.6 [Q96K19-1]
ENST00000319104.7 [Q96K19-3]
ENST00000240159.8 [Q96K19-5]
ENST00000534961.5 [Q96K19-1]