RNASE7 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of RNASE7 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RNASE7 at tissue level.

III. Associated gene sets

GO_0050829Biological processdefense response to Gram-negative bacterium
GO_0051715Biological processcytolysis in another organism
GO_0061844Biological processantimicrobial humoral immune response mediated by antimicrobial peptide
GO_0050832Biological processdefense response to fungus
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0019731Biological processantibacterial humoral response
GO_0045087Biological processinnate immune response
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005737Cellular componentcytoplasm
GO_0042834Molecular functionpeptidoglycan binding
GO_0001530Molecular functionlipopolysaccharide binding
GO_0004540Molecular functionRNA nuclease activity
GO_0004519Molecular functionendonuclease activity
GO_0003676Molecular functionnucleic acid binding

IV. Literature review

[source]
Gene nameRNASE7
Protein nameRibonuclease 7 (RNase 7) (EC 3.1.27.-) (Skin-derived antimicrobial protein 2) (SAP-2)
SynonymsUNQ2516/PRO6006
DescriptionFUNCTION: Exhibits a potent RNase activity . Has broad-spectrum antimicrobial activity against many pathogenic microorganisms including uropathogenic E.coli (UPEC), and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium . Causes loss of bacterial membrane integrity . Probably contributes to urinary tract sterility . Bactericidal activity is independent of RNase activity . .

AccessionsQ9H1E1
ENST00000298690.5
ENST00000481538.1