RMND5B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0005829Cellular componentcytosol
GO_0034657Cellular componentGID complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameRMND5B
Protein nameE3 ubiquitin-protein transferase RMND5B (EC 2.3.2.27) (Protein RMD5 homolog B)
RING-type E3 ubiquitin transferase (EC 2.3.2.27)
Required for meiotic nuclear division 5 homolog B
SynonymsUNQ2508/PRO5996
DescriptionFUNCTION: Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex . Catalytic activity of the complex is required for normal cell proliferation . The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 . .

AccessionsENST00000313386.9 [Q96G75-1]
D6R9A2
D6RFE6
D6RIF9
ENST00000502814.5
ENST00000512663.5
ENST00000515098.5 [Q96G75-1]
F5H6G4
ENST00000542098.2
D6RER3
D6RFK1
ENST00000512811.5
Q96G75
ENST00000507457.5
ENST00000508647.5