RILPL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0003382Biological processepithelial cell morphogenesis
GO_1903445Biological processprotein transport from ciliary membrane to plasma membrane
GO_0007263Biological processnitric oxide mediated signal transduction
GO_0005814Cellular componentcentriole
GO_0005813Cellular componentcentrosome
GO_0005929Cellular componentcilium
GO_0036064Cellular componentciliary basal body
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0051959Molecular functiondynein light intermediate chain binding
GO_0046983Molecular functionprotein dimerization activity
GO_0005515Molecular functionprotein binding
GO_0031267Molecular functionsmall GTPase binding

IV. Literature review

[source]
Gene nameRILPL1
Protein nameRILP-like protein 1 (Rab-interacting lysosomal-like protein 1)
Rab interacting lysosomal protein like 1
SynonymsRLP1
DescriptionFUNCTION: Plays a role in the regulation of cell shape and polarity (By similarity). Plays a role in cellular protein transport, including protein transport away from primary cilia (By similarity). Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus (By similarity). Competes with SIAH1 for binding GAPDH (By similarity). Does not regulate lysosomal morphology and distribution . Binds to RAB10 following LRRK2-mediated RAB10 phosphorylation which leads to inhibition of ciliogenesis . .

AccessionsQ5EBL4
ENST00000636882.1
ENST00000376874.9 [Q5EBL4-1]
A0A1B0GVV3