RILP report

I. Expression across cell types

Insufficient scRNA-seq data for expression of RILP at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RILP at tissue level.

III. Associated gene sets

GO_0042177Biological processnegative regulation of protein catabolic process
GO_0060271Biological processcilium assembly
GO_0010796Biological processregulation of multivesicular body size
GO_0045732Biological processpositive regulation of protein catabolic process
GO_0008333Biological processendosome to lysosome transport
GO_0032509Biological processendosome transport via multivesicular body sorting pathway
GO_0015031Biological processprotein transport
GO_0045022Biological processearly endosome to late endosome transport
GO_0070676Biological processintralumenal vesicle formation
GO_0031902Cellular componentlate endosome membrane
GO_0005764Cellular componentlysosome
GO_0032991Cellular componentprotein-containing complex
GO_0005770Cellular componentlate endosome
GO_0005737Cellular componentcytoplasm
GO_0030670Cellular componentphagocytic vesicle membrane
GO_0036064Cellular componentciliary basal body
GO_0005765Cellular componentlysosomal membrane
GO_0031267Molecular functionsmall GTPase binding
GO_0051959Molecular functiondynein light intermediate chain binding
GO_0046983Molecular functionprotein dimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRILP
Protein nameRab-interacting lysosomal protein
Rab interacting lysosomal protein
REST/NRSF-interacting LIM domain protein
SynonymsPP10141
DescriptionFUNCTION: Rab effector playing a role in late endocytic transport to degradative compartments . Involved in the regulation of lysosomal morphology and distribution . Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments . Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes . .

AccessionsENST00000301336.7 [Q96NA2-1]
A0A0J9YWQ1
ENST00000622136.2 [Q96NA2-1]
I3L1U0
Q687H3
Q96NA2
ENST00000574810.5
Q687H4
ENST00000633176.1