RHBDF1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of RHBDF1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RHBDF1 at tissue level.

III. Associated gene sets

GO_0015031Biological processprotein transport
GO_0050709Biological processnegative regulation of protein secretion
GO_0050708Biological processregulation of protein secretion
GO_0008283Biological processcell population proliferation
GO_0061136Biological processregulation of proteasomal protein catabolic process
GO_0016477Biological processcell migration
GO_0042058Biological processregulation of epidermal growth factor receptor signaling pathway
GO_0000139Cellular componentGolgi membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0004252Molecular functionserine-type endopeptidase activity
GO_0005515Molecular functionprotein binding
GO_0019838Molecular functiongrowth factor binding

IV. Literature review

[source]
Gene nameRHBDF1
Protein nameInactive rhomboid protein 1 (iRhom1) (Epidermal growth factor receptor-related protein) (Rhomboid 5 homolog 1) (Rhomboid family member 1) (p100hRho)
Inactive rhomboid protein (iRhom) (Rhomboid family member) (Rhomboid veinlet-like protein)
Rhomboid 5 homolog 1 (Drosophila)
Rhomboid 5 homolog 1
SynonymsC16orf8
DIST1
Z69719.3-004
Z69719.3-012
Z69719.3-008
Z69719.3-010
IRHOM1
DescriptionFUNCTION: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. .

FUNCTION: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. .

FUNCTION: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. .

FUNCTION: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. .

FUNCTION: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. .

AccessionsB8ZZ07
A2IDA2
ENST00000450643.5
ENST00000417043.5
Q4TT60
F8WBS4
A0A1B0GXG1
Q4TT58
F8WCF7
Q96CC6
ENST00000448893.1
ENST00000419764.1
ENST00000262316.10
ENST00000428730.5
H0Y6L9