RFXANK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007265Biological processRas protein signal transduction
GO_0045348Biological processpositive regulation of MHC class II biosynthetic process
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0045171Cellular componentintercellular bridge
GO_0005634Cellular componentnucleus
GO_0042826Molecular functionhistone deacetylase binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRFXANK
Protein nameRFXANK protein
Regulatory factor X associated ankyrin containing protein
Regulatory factor X associated ankyrin containing protein (Regulatory factor X-associated ankyrin-containing protein, isoform CRA_c)
DNA-binding protein RFXANK (Ankyrin repeat family A protein 1) (Regulatory factor X subunit B) (RFX-B) (Regulatory factor X-associated ankyrin-containing protein)
SynonymsRFXB
hCG_38560
ANKRA1
DescriptionFUNCTION: Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator/CIITA. May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters . May also potentiate the activation of RAF1 (By similarity). .; FUNCTION: Isoform 2 is not involved in the positive regulation of MHC class II genes. .

AccessionsENST00000456252.7 [O14593-3]
ENST00000421262.7
ENST00000536253.1
ENST00000544923.5
H0YFU5
H0YGQ6
ENST00000392324.8
ENST00000540981.5
ENST00000535017.1
Q6IB23
ENST00000593273.5
O14593
H0YFZ0
ENST00000407360.7 [O14593-1]
A0A024R7P0
F5H7D2
F5GY33
K7ENE6
ENST00000303088.9 [O14593-1]