RFNG report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RFNG at tissue level.

III. Associated gene sets

GO_0008593Biological processregulation of Notch signaling pathway
GO_0045747Biological processpositive regulation of Notch signaling pathway
GO_0030154Biological processcell differentiation
GO_0007399Biological processnervous system development
GO_0007389Biological processpattern specification process
GO_0009887Biological processanimal organ morphogenesis
GO_0000139Cellular componentGolgi membrane
GO_0005576Cellular componentextracellular region
GO_0033829Molecular functionO-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity
GO_0046872Molecular functionmetal ion binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameRFNG
Protein nameRFNG protein
Beta-1,3-N-acetylglucosaminyltransferase radical fringe (EC 2.4.1.222) (O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase)
SynonymshCG_1820367
DescriptionFUNCTION: Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in enhancement of NOTCH1 activation by DLL1 and JAG1. May be involved in limb formation and in neurogenesis. .

AccessionsB4DXP6
J3QLN0
ENST00000310496.9
F5H3H7
A6H8Z0
ENST00000578356.1
Q9Y644
ENST00000429557.7