RETREG3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071786Biological processendoplasmic reticulum tubular network organization
GO_0061709Biological processreticulophagy
GO_0010976Biological processpositive regulation of neuron projection development
GO_0030574Biological processcollagen catabolic process
GO_0071782Cellular componentendoplasmic reticulum tubular network
GO_0032991Cellular componentprotein-containing complex
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0140506Molecular functionendoplasmic reticulum-autophagosome adaptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRETREG3
Protein nameReticulophagy regulator 3
Reticulophagy regulator family member 3
SynonymsFAM134C
DescriptionFUNCTION: Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress . When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins . Promotes ER membrane curvature and ER tubulation required for subsequent ER fragmentation and engulfment into autophagosomes . Required for collagen quality control in a LIR motif-dependent manner (By similarity). Mediates NRF1-enhanced neurite outgrowth . .

AccessionsENST00000585726.5
ENST00000585894.5
ENST00000586870.5
K7ENF4
ENST00000591547.5
K7EQI9
ENST00000593251.5
K7EMF4
K7ENZ6
K7EJ42
K7ELM8
ENST00000589797.5
ENST00000590541.1
ENST00000588423.1
K7EPD0
ENST00000309428.10 [Q86VR2-1]
K7EJ34
Q86VR2