RETREG2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007029Biological processendoplasmic reticulum organization
GO_0061709Biological processreticulophagy
GO_0030574Biological processcollagen catabolic process
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0140506Molecular functionendoplasmic reticulum-autophagosome adaptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRETREG2
Protein nameReticulophagy regulator 2
Reticulophagy regulator family member 2
SynonymsFAM134A
C2orf17
MAG2
DescriptionFUNCTION: Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress . When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins . Required for collagen quality control in a LIR motif-independent manner (By similarity). .

AccessionsC9J3K5
C9JIF3
ENST00000452293.5
ENST00000430297.7
ENST00000452022.1
F8WAL5
F8WE68
ENST00000273048.2
H7C3D5
ENST00000420189.1
Q8NC44
ENST00000458520.5