REG3G report

I. Expression across cell types

Insufficient scRNA-seq data for expression of REG3G at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of REG3G at tissue level.

III. Associated gene sets

GO_0002755Biological processMyD88-dependent toll-like receptor signaling pathway
GO_0045617Biological processnegative regulation of keratinocyte differentiation
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0061844Biological processantimicrobial humoral immune response mediated by antimicrobial peptide
GO_0006953Biological processacute-phase response
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0010838Biological processpositive regulation of keratinocyte proliferation
GO_0043434Biological processresponse to peptide hormone
GO_0090303Biological processpositive regulation of wound healing
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005737Cellular componentcytoplasm
GO_0070492Molecular functionoligosaccharide binding
GO_0038023Molecular functionsignaling receptor activity
GO_0042834Molecular functionpeptidoglycan binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameREG3G
Protein nameRegenerating islet-derived protein 3-gamma (REG-3-gamma) (Pancreatitis-associated protein 1B) (PAP-1B) (Pancreatitis-associated protein IB) (PAP IB) (Regenerating islet-derived protein III-gamma) (REG III) (Reg III-gamma) [Cleaved into: Regenerating islet-derived protein 3-gamma 16.5 kDa form; Regenerating islet-derived protein 3-gamma 15 kDa form]
SynonymsPAP1B
UNQ429/PRO162
DescriptionFUNCTION: Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. .; FUNCTION: Acts as a hormone in response to different stimuli like anti-inflammatory signals, such as IL17A, or gut microbiome. Is secreted by different cell types to activate its receptor EXTL3 and induce cell specific signaling pathways. Induced by IL17A in keratinocytes, regulates keratinocyte proliferation and differentiation after skin injury. In parallel, inhibits skin inflammation through the inhibition of inflammatory cytokines such as IL6 and TNF. Induced by IL22 in lung epithelial cells, inhibits cytokine production and regulates allergic airway inflammation. Induced in small intestine by inulin-enriched diet and Lactobacillus gasseri enriched microbiome, plays a role in the improvement of gut barrier function, the regulation of energy balance and glucose levels. Modulates microbiota composition in duodenal contents. Produced by nociceptor in response to endotoxins, prevents endotoxic death by targeting kynurenine pathway in microglia. .; FUNCTION: [Regenerating islet-derived protein 3-gamma 16.5 kDa form]: Has bacteriostatic activity. .; FUNCTION: [Regenerating islet-derived protein 3-gamma 15 kDa form]: Has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. .

AccessionsENST00000409471.1 [Q6UW15-2]
Q6UW15
ENST00000393897.6 [Q6UW15-1]
ENST00000272324.10 [Q6UW15-1]