REC114 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of REC114 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of REC114 at tissue level.

III. Associated gene sets

GO_0006310Biological processDNA recombination
GO_0007283Biological processspermatogenesis
GO_0042138Biological processmeiotic DNA double-strand break formation
GO_0048477Biological processoogenesis
GO_0005694Cellular componentchromosome
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameREC114
Protein nameHCG40828, isoform CRA_a (REC114 meiotic recombination protein)
Meiotic recombination protein REC114
SynonymshCG_40828
C15orf60
DescriptionFUNCTION: Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1 and MEI4, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Required for spermatogenesis and oogenesis (By similarity). .

AccessionsENST00000331090.11
H0YKR2
ENST00000560581.1
Q7Z4M0