RCL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000479Biological processendonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO_0000447Biological processendonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO_0008150Biological processbiological_process
GO_0000480Biological processendonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO_0042274Biological processribosomal small subunit biogenesis
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0032040Cellular componentsmall-subunit processome
GO_0004521Molecular functionRNA endonuclease activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRCL1
Protein nameRNA 3'-terminal phosphate cyclase-like protein
RNA terminal phosphate cyclase like 1
SynonymsRPCL1
RTC2
HSPC338
RPC2
RNAC
DescriptionFUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome . Does not have cyclase activity (By similarity). .

AccessionsENST00000441844.2
ENST00000381730.5 [Q9Y2P8-2]
Q5VZU3
Q5VYW8
ENST00000442869.5
Q5VZU2
Q9Y2P8
ENST00000381732.3
ENST00000381728.5 [Q9Y2P8-2]
ENST00000448872.6 [Q9Y2P8-2]
ENST00000381750.9 [Q9Y2P8-1]