RCHY1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0072344Biological processrescue of stalled ribosome
GO_0070987Biological processerror-free translesion synthesis
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0000151Cellular componentubiquitin ligase complex
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0008270Molecular functionzinc ion binding
GO_0002039Molecular functionp53 binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRCHY1
Protein nameRING finger and CHY zinc finger domain-containing protein 1 (EC 2.3.2.27) (Androgen receptor N-terminal-interacting protein) (CH-rich-interacting match with PLAG1) (E3 ubiquitin-protein ligase Pirh2) (RING finger protein 199) (RING-type E3 ubiquitin transferase RCHY1) (Zinc finger protein 363) (p53-induced RING-H2 protein) (hPirh2)
RCHY1 protein
PIRH2F
Ring finger and CHY zinc finger domain containing 1
PIRH2E
SynonymsRNF199
ARNIP
CHIMP
ZNF363
PIRH2
DescriptionFUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins, including p53/TP53, TP73, HDAC1 and CDKN1B . Mediates ubiquitination and degradation of p53/TP53; preferentially acts on tetrameric p53/TP53 . Catalyzes monoubiquitinates the translesion DNA polymerase POLH . Involved in the ribosome-associated quality control (RQC) pathway, which mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes: RCHY1 acts downstream of NEMF and recognizes CAT tails associated with stalled nascent chains, leading to their ubiquitination and degradation . .; FUNCTION: [Isoform 4]: Has no E3 ubiquitin-protein ligase activity. .

AccessionsENST00000512706.5 [Q96PM5-6]
G3FDP5
ENST00000513909.5
Q96BL1
ENST00000380840.6 [Q96PM5-7]
ENST00000324439.10 [Q96PM5-1]
G3FDP4
ENST00000507014.1 [Q96PM5-8]
Q96PM5
ENST00000504085.5
D6RAF6
ENST00000505105.5 [Q96PM5-4]
H0YAI4
ENST00000513257.5 [Q96PM5-2]