RBPMS2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RBPMS2 at tissue level.

III. Associated gene sets

GO_0048661Biological processpositive regulation of smooth muscle cell proliferation
GO_0030514Biological processnegative regulation of BMP signaling pathway
GO_0048557Biological processembryonic digestive tract morphogenesis
GO_0000381Biological processregulation of alternative mRNA splicing, via spliceosome
GO_0051151Biological processnegative regulation of smooth muscle cell differentiation
GO_0005829Cellular componentcytosol
GO_0010494Cellular componentcytoplasmic stress granule
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0003729Molecular functionmRNA binding

IV. Literature review

[source]
Gene nameRBPMS2
Protein nameRNA-binding protein with multiple splicing 2 (RNA binding protein, mRNA processing factor 2)
Synonyms
DescriptionFUNCTION: RNA-binding protein involved in the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system . Binds NOG mRNA, the major inhibitor of the bone morphogenetic protein (BMP) pathway. Mediates an increase of NOG mRNA levels, thereby contributing to the negative regulation of BMP signaling pathway and promoting reversible dedifferentiation and proliferation of smooth muscle cells (By similarity). Acts as a pre-mRNA alternative splicing regulator (By similarity). Mediates ACTN1 and FLNB alternative splicing (By similarity). Likely binds to mRNA tandem CAC trinucleotide or CA dinucleotide motifs . .

AccessionsENST00000560606.5 [Q6ZRY4-2]
Q6ZRY4
ENST00000300069.5 [Q6ZRY4-1]