RBM46 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of RBM46 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RBM46 at tissue level.

III. Associated gene sets

GO_0007140Biological processmale meiotic nuclear division
GO_0001829Biological processtrophectodermal cell differentiation
GO_0051728Biological processcell cycle switching, mitotic to meiotic cell cycle
GO_0007283Biological processspermatogenesis
GO_0048255Biological processmRNA stabilization
GO_0007143Biological processfemale meiotic nuclear division
GO_0048477Biological processoogenesis
GO_0048515Biological processspermatid differentiation
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0003729Molecular functionmRNA binding

IV. Literature review

[source]
Gene nameRBM46
Protein nameProbable RNA-binding protein 46 (Cancer/testis antigen 68) (CT68) (RNA-binding motif protein 46)
RNA binding motif protein 46
Synonyms
DescriptionFUNCTION: Essential for male and female fertility, playing a crucial role in regulating germ cell development by ensuring the proper progression of meiosis prophase I (By similarity). Regulates mitotic-to-meiotic transition in spermatogenesis by forming a complex with MEIOC and YTHDC2 which recognizes and down-regulates mitotic transcripts for a successful meiotic entry (By similarity). Required for normal synaptonemal complex formation during meiosis, binding meiotic cohesin subunit mRNAs containing GCCUAU/GUUCGA motifs in their 3'UTRs regions and positively regulating their translation (By similarity). Required for spermatogonial differentiation in both developing and adult testis (By similarity). .

AccessionsENST00000510397.5 [Q8TBY0-2]
ENST00000512640.1
D6RF41
Q8TBY0
ENST00000281722.8 [Q8TBY0-1]
ENST00000514866.5 [Q8TBY0-3]