RBBP5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006974Biological processDNA damage response
GO_0043627Biological processresponse to estrogen
GO_0045815Biological processtranscription initiation-coupled chromatin remodeling
GO_0005730Cellular componentnucleolus
GO_0048188Cellular componentSet1C/COMPASS complex
GO_0044665Cellular componentMLL1/2 complex
GO_0035097Cellular componenthistone methyltransferase complex
GO_0005654Cellular componentnucleoplasm
GO_0071339Cellular componentMLL1 complex
GO_0044666Cellular componentMLL3/4 complex
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0042393Molecular functionhistone binding
GO_0000976Molecular functiontranscription cis-regulatory region binding

IV. Literature review

[source]
Gene nameRBBP5
Protein nameRetinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3)
SynonymsRBQ3
DescriptionFUNCTION: In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity). Does not affect ES cell self-renewal (By similarity). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters . As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3 . Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation . In association with ASH2L and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B . .

AccessionsENST00000264515.11 [Q15291-1]
ENST00000367164.1 [Q15291-2]
Q15291