RAP2A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046328Biological processregulation of JNK cascade
GO_0045198Biological processestablishment of epithelial cell apical/basal polarity
GO_0071466Biological processcellular response to xenobiotic stimulus
GO_0072659Biological processprotein localization to plasma membrane
GO_0048814Biological processregulation of dendrite morphogenesis
GO_0045184Biological processestablishment of protein localization
GO_0099072Biological processregulation of postsynaptic membrane neurotransmitter receptor levels
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0030033Biological processmicrovillus assembly
GO_0032486Biological processRap protein signal transduction
GO_0030036Biological processactin cytoskeleton organization
GO_0051963Biological processregulation of synapse assembly
GO_0031954Biological processpositive regulation of protein autophosphorylation
GO_0030336Biological processnegative regulation of cell migration
GO_0008104Biological processprotein localization
GO_0030496Cellular componentmidbody
GO_0098685Cellular componentSchaffer collateral - CA1 synapse
GO_0005886Cellular componentplasma membrane
GO_0055037Cellular componentrecycling endosome
GO_0097060Cellular componentsynaptic membrane
GO_0055038Cellular componentrecycling endosome membrane
GO_0005829Cellular componentcytosol
GO_0019003Molecular functionGDP binding
GO_0003925Molecular functionG protein activity
GO_0000287Molecular functionmagnesium ion binding
GO_0005525Molecular functionGTP binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameRAP2A
Protein nameRas-related protein Rap-2a (EC 3.6.5.2) (RbBP-30)
RAP2A, member of RAS oncogene family
Synonyms
DescriptionFUNCTION: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading. .

AccessionsENST00000476869.1
ENST00000245304.5
P10114
F6U784