RANBP3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006611Biological processprotein export from nucleus
GO_0005737Cellular componentcytoplasm
GO_0005654Cellular componentnucleoplasm
GO_0005643Cellular componentnuclear pore
GO_0005634Cellular componentnucleus
GO_0070412Molecular functionR-SMAD binding
GO_0005515Molecular functionprotein binding
GO_0005096Molecular functionGTPase activator activity

IV. Literature review

[source]
Gene nameRANBP3
Protein nameRAN binding protein 3
Ran-binding protein 3 (RanBP3)
RAN binding protein 3 (cDNA FLJ58549, highly similar to Ran-binding protein 3)
Synonyms
DescriptionFUNCTION: Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. .

AccessionsENST00000340578.10 [Q9H6Z4-1]
K7EIJ4
ENST00000592133.5
K7EMT3
ENST00000588010.5
ENST00000592771.5
K7ENJ2
K7EQB8
ENST00000591092.5
ENST00000585339.5
ENST00000587263.5
K7ERD4
ENST00000587479.2
Q9H6Z4
K7EMH9
ENST00000590623.5
K7ENB9
ENST00000034275.12 [Q9H6Z4-3]
K7EPW1
B7Z7F3
ENST00000592621.5
ENST00000591333.5
ENST00000439268.6 [Q9H6Z4-2]
K7EID7
ENST00000587463.5
ENST00000591736.5
K7ESQ0
K7EN31
K7EJ17
ENST00000589353.5