RAD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006974Biological processDNA damage response
GO_0006281Biological processDNA repair
GO_0051598Biological processmeiotic recombination checkpoint signaling
GO_0071479Biological processcellular response to ionizing radiation
GO_0021762Biological processsubstantia nigra development
GO_0000077Biological processDNA damage checkpoint signaling
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005694Cellular componentchromosome
GO_0005654Cellular componentnucleoplasm
GO_0030896Cellular componentcheckpoint clamp complex
GO_0005634Cellular componentnucleus
GO_0008311Molecular functiondouble-stranded DNA 3'-5' DNA exonuclease activity
GO_0005515Molecular functionprotein binding
GO_0003684Molecular functiondamaged DNA binding

IV. Literature review

[source]
Gene nameRAD1
Protein nameRAD1 checkpoint DNA exonuclease
Cell cycle checkpoint protein RAD1 (hRAD1) (Rad1-like DNA damage checkpoint protein)
SynonymsREC1
DescriptionFUNCTION: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair . The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex . Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER) . The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates . The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase . .

AccessionsENST00000341754.8 [O60671-1]
D6R9A1
ENST00000325577.8 [O60671-3]
ENST00000382038.7 [O60671-1]
O60671
ENST00000513914.5