I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| renal alpha-intercalated cell | 3 studies | 32% ± 11% | |
| glutamatergic neuron | 3 studies | 18% ± 1% | |
| transit amplifying cell | 3 studies | 26% ± 4% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| renal alpha-intercalated cell | 3 studies | 32% ± 11% | |
| glutamatergic neuron | 3 studies | 18% ± 1% | |
| transit amplifying cell | 3 studies | 26% ± 4% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 3 studies | 16% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 99% | 1232.71 | 1431 / 1445 | 100% | 52.62 | 183 / 183 |
| stomach | 99% | 805.53 | 355 / 359 | 100% | 44.95 | 285 / 286 |
| intestine | 100% | 1254.05 | 964 / 966 | 99% | 47.48 | 520 / 527 |
| uterus | 98% | 408.26 | 167 / 170 | 99% | 56.71 | 453 / 459 |
| breast | 98% | 483.62 | 451 / 459 | 98% | 41.34 | 1101 / 1118 |
| lung | 99% | 860.02 | 571 / 578 | 98% | 38.17 | 1131 / 1155 |
| bladder | 100% | 640.00 | 21 / 21 | 97% | 42.00 | 487 / 504 |
| skin | 100% | 2443.31 | 1808 / 1809 | 97% | 34.81 | 456 / 472 |
| brain | 99% | 696.64 | 2615 / 2642 | 96% | 26.72 | 678 / 705 |
| ovary | 78% | 260.36 | 141 / 180 | 99% | 37.22 | 426 / 430 |
| kidney | 96% | 441.78 | 85 / 89 | 70% | 10.50 | 632 / 901 |
| adrenal gland | 80% | 297.35 | 206 / 258 | 67% | 12.49 | 153 / 230 |
| prostate | 92% | 357.24 | 225 / 245 | 53% | 6.80 | 266 / 502 |
| pancreas | 28% | 79.68 | 93 / 328 | 89% | 17.87 | 159 / 178 |
| thymus | 78% | 234.91 | 511 / 653 | 30% | 7.10 | 184 / 605 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 42.61 | 29 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 66.98 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 9.02 | 1 / 1 |
| spleen | 100% | 852.41 | 240 / 241 | 0% | 0 | 0 / 0 |
| adipose | 99% | 508.22 | 1187 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 96% | 439.65 | 1282 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 85% | 1772.48 | 786 / 929 | 0% | 0 | 0 / 0 |
| liver | 24% | 104.19 | 55 / 226 | 55% | 10.00 | 225 / 406 |
| muscle | 77% | 285.51 | 617 / 803 | 0% | 0 | 0 / 0 |
| heart | 65% | 206.66 | 556 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 61% | 7.22 | 49 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0007283 | Biological process | spermatogenesis |
| GO_0045995 | Biological process | regulation of embryonic development |
| GO_0006811 | Biological process | monoatomic ion transport |
| GO_0051056 | Biological process | regulation of small GTPase mediated signal transduction |
| GO_0051988 | Biological process | regulation of attachment of spindle microtubules to kinetochore |
| GO_0000281 | Biological process | mitotic cytokinesis |
| GO_0030218 | Biological process | erythrocyte differentiation |
| GO_0051256 | Biological process | mitotic spindle midzone assembly |
| GO_0008272 | Biological process | sulfate transport |
| GO_0007266 | Biological process | Rho protein signal transduction |
| GO_0000915 | Biological process | actomyosin contractile ring assembly |
| GO_0032467 | Biological process | positive regulation of cytokinesis |
| GO_0007405 | Biological process | neuroblast proliferation |
| GO_0030496 | Cellular component | midbody |
| GO_0001669 | Cellular component | acrosomal vesicle |
| GO_0005874 | Cellular component | microtubule |
| GO_0072686 | Cellular component | mitotic spindle |
| GO_0009898 | Cellular component | cytoplasmic side of plasma membrane |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0090543 | Cellular component | Flemming body |
| GO_0051233 | Cellular component | spindle midzone |
| GO_0097149 | Cellular component | centralspindlin complex |
| GO_0005829 | Cellular component | cytosol |
| GO_0032154 | Cellular component | cleavage furrow |
| GO_0005819 | Cellular component | spindle |
| GO_0005634 | Cellular component | nucleus |
| GO_0043015 | Molecular function | gamma-tubulin binding |
| GO_0005547 | Molecular function | phosphatidylinositol-3,4,5-trisphosphate binding |
| GO_0048487 | Molecular function | beta-tubulin binding |
| GO_0019901 | Molecular function | protein kinase binding |
| GO_0005096 | Molecular function | GTPase activator activity |
| GO_0030674 | Molecular function | protein-macromolecule adaptor activity |
| GO_0043014 | Molecular function | alpha-tubulin binding |
| GO_0008017 | Molecular function | microtubule binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | RACGAP1 |
| Protein name | Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) Rac GTPase activating protein 1 RACGAP1 |
| Synonyms | KIAA1478 MGCRACGAP |
| Description | FUNCTION: Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis . Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity . Has a critical role in erythropoiesis . Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. . |
| Accessions | ENST00000427314.6 F8VV47 ENST00000551145.5 ENST00000548824.5 ENST00000549777.5 F8VUW9 ENST00000546723.5 ENST00000551260.5 F8VXH1 ENST00000312377.10 F8VYH6 F8W0L1 F8VVY0 ENST00000551016.5 ENST00000548320.5 ENST00000550149.5 ENST00000551876.5 F8VV39 ENST00000552921.5 ENST00000546595.5 ENST00000548644.5 F8VQF5 ENST00000550651.5 H0YIK5 F8VZ66 ENST00000548598.5 F8VWX0 ENST00000552310.5 ENST00000548247.1 Q9H0H5 F8W1E5 ENST00000548961.5 F8VRL2 A0A2X0U4T9 F8VRD2 F8VVE5 F8VWY4 F8W1T4 ENST00000552157.5 F8VQZ5 ENST00000547905.5 F8VS54 F8VV37 F8VZ41 ENST00000552004.2 ENST00000546764.5 ENST00000454520.6 ENST00000546786.5 ENST00000549342.1 |
